Splanchnic ischaemia and multiple organ failure

The Splanchnic Model of Multiple Organ Failure

Ischemia signifies failure to satisfy the metabolic needs of the cell secondary to either impaired oxygen delivery or the impairment of cellular oxygen extraction and utilization. Incomplete splanchnic cellular resuscitation has been associated with the development of multiple organ system failure and increased mortality in the critically ill patient (1,2). For many years, the merits of augment...

Clinical review: Splanchnic ischaemia

Inadequate splanchnic perfusion is associated with increased morbidity and mortality, particularly if liver dysfunction coexists. Heart failure, increased intra-abdominal pressure, haemodialysis and the presence of obstructive sleep apnoea are among the multiple clinical conditions that are associated with impaired splanchnic perfusion in critically ill patients. Total liver blood flow is belie...

Nutrition and Multiple Organ Failure

Responses of the splanchnic circulation to ischaemia.

The distribution of the cardiac output is conventionally shared between six major circulatory components, that is, to the brain, heart, kidneys, bone and skeletal muscle, skin and viscera. This last comprises the splanchnic circulation, which arrives through the three great visceral arteries (coeliac axis, superior and inferior mesenteric artery) and is drained, via the liver, into the hepatic ...

Burn shock and multiple organ failure syndromes

Critical condition, developing in patients with burns during the burn shock more often produce the development of nonspecific reactions in the body, manifested as the system or the organ insufficiency and are determined by the term «syndrome of poly organ insufficiency» (SPOI). The course and treatment of 189 patients with burn shock have been analyzed. With the purpose of investigation all pat...